Simple to use

THROMBATE III® dosing guidelines for patients with hereditary antithrombin (AT) deficiency include patients undergoing surgery and pregnant women.


Easy to administer1

  • Bolus intravenous infusion-not continuous infusion

One dosing formula1

  • Loading dose on day 1

Maintenance dose administered every 24 hours for 2 to 8 days

  • 60% of the initial loading dose
  • Maintain AT levels between 80% and 120%
  • Adjustments in the maintenance dose and/or interval between doses should be made based on actual AT level achievedb

Convenient to store and reconstitute



  • No refrigeration required-store at room temperature (25°C, 77°F)
  • Single-use vial (500 IU potency)
  • Sterile water for Injection (10 mL), transfer needle, and filter needle provided

THROMBATE III® (antithrombin III [human]) is indicated in patients with hereditary antithrombin deficiency for treatment and prevention of thromboembolism and for prevention of perioperative and peripartum thromboembolism.

Hypersensitivity reactions may occur. Should evidence of an acute hypersensitivity reaction be observed, promptly interrupt the infusion and begin appropriate treatment.

Because THROMBATE III is made from human blood, it may carry a risk of transmitting infectious agents, eg, viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent. There is also the possibility that unknown infectious agents may be present in the product.

Perform coagulation tests to avoid excessive or insufficient anticoagulation and monitor for bleeding or thrombosis. Measure functional plasma AT levels with amidolytic or clotting assays; do not use immunoassays.

In clinical studies, the most common adverse reactions (≥5% of subjects) were dizziness, chest discomfort, nausea, dysgeusia, and pain (cramps).

The anticoagulant effect of heparin is enhanced by concurrent treatment with THROMBATE III in patients with hereditary AT deficiency. Thus, in order to avoid bleeding, the dosage of heparin (or low molecular weight heparin) may need to be reduced during treatment with THROMBATE III.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch, or call 1-800-FDA-1088.


Reference

  1. THROMBATE III® (antithrombin III [human]) Prescribing Information. Grifols.