THROMBATE III MOA and the impact of heparin

  • 80% of the natural anticoagulant effect against thrombin is dependent on antithrombin (AT)1,2
  • AT activity inhibits many clotting factors in the coagulation cascade1-5 
Consider the role of AT in situations of high thrombotic risk

AT levels and heparin

Image showing how administration of heparin increases the anticlotting effects of AT

The administration of heparin increases the anticlotting effects of AT 1000-fold.1,2,6,7

  • Signs of heparin (enoxaparin) resistance could suggest an inherited clotting disorder, such as hereditary AT deficiency


Find out more by downloading the MOA fact sheet.



THROMBATE III® (antithrombin III [human]) is indicated in patients with hereditary antithrombin deficiency for treatment and prevention of thromboembolism and for prevention of perioperative and peripartum thromboembolism.

Hypersensitivity reactions may occur. Should evidence of an acute hypersensitivity reaction be observed, promptly interrupt the infusion and begin appropriate treatment.

Because THROMBATE III is made from human blood, it may carry a risk of transmitting infectious agents, eg, viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent. There is also the possibility that unknown infectious agents may be present in the product.

Perform coagulation tests to avoid excessive or insufficient anticoagulation and monitor for bleeding or thrombosis. Measure functional plasma AT levels with amidolytic or clotting assays; do not use immunoassays.

In clinical studies, the most common adverse reactions (≥ 5% of subjects) were dizziness, chest discomfort, nausea, dysgeusia, and pain (cramps).

The anticoagulant effect of heparin is enhanced by concurrent treatment with THROMBATE III in patients with hereditary AT deficiency. Thus, in order to avoid bleeding, the dosage of heparin (or low molecular weight heparin) may need to be reduced during treatment with THROMBATE III.

Please see full Prescribing Information for THROMBATE III.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

References: 1. Maclean PS, Tait RC. Drugs. 2007;67(10):1429-1440. 2. Li W, Johnson DJ, Esmon CT, Huntington JA. Nat Struct Mol Biol. 2004;11(9):857-862. 3. James AH, Konkle BA, Bauer KA. Int J Womens Health. 2013;5:233-241. 4. Davi G, Patrono C. N Engl J Med. 2007;357(24):2482-2494. 5. Wolberg AS. Blood Rev. 2007;21(3):131-142. 6. Patnaik MM, Moll S. Haemophilia. 2008;14(6):1229-1239. 7. Kottke-Marchant K, Duncan A. Arch Pathol Lab Med. 2002;126(11):1326-1336.